What is HPMC Structure? A Complete Guide for Applications

HPMC consists of a cellulose backbone and hydroxyl groups (-OH) partially substituted by methoxy groups (-OCH3) and hydroxypropyl groups (-CH2CHOHCH3).

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Hydroxypropyl groups are highly hydrophilic and help HPMC disperse in water.

Methyl groups are highly hydrophobic and affect film-forming properties and thermal stability.

The performance of HPMC varies greatly depending on the ratio of these two groups.

The molecular weight of HPMC ranges from tens of thousands to hundreds of thousands, which directly affects viscosity:

HPMC with higher molecular weight has higher viscosity and is suitable for thickening applications such as cement mortar or coatings.

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Variants with lower molecular weight can be used in scenarios where rapid dissolution is required, such as pharmaceutical suspensions and ophthalmic solutions.

Tablet coating: provides a smooth protective coating for controlled release.

Capsules: used for overall coating of capsules, which is not easy to become brittle under low moisture conditions.

Suspensions and ophthalmic solutions: ensure appropriate viscosity and stability.

Controlled release drugs: HPMC can be used in hydrophilic matrix tablets to adjust drug release time.

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